Paducah is a city in and the county seat of McCracken County, Kentucky, United States. The largest city in the Jackson Purchase region, it is located at the confluence of the Tennessee and the Ohio Rivers. Twenty blocks of the city's downtown have been designated as a historic district and listed on the National Register of Historic Places.

Paducah is the hub of its micropolitan area, which includes McCracken, Ballard, and Livingston counties in Kentucky and Massac County in Illinois.